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Neural crest cells migrate from the hindbrain in distinct streams.How many neural crest cells streams are there in the hindbrain?


A) 2
B) 3
C) 4
D) 5
E) 7

F) A) and C)
G) A) and E)

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The mesoderm forms which derivative of the pharyngeal apparatus?


A) Aortic arch muscle coats
B) Cartilaginous bars
C) Cranial nerves
D) Muscle plates

E) A) and B)
F) A) and D)

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A child is diagnosed with Treacher Collins syndrome,which results from a mutation in the gene TCOF1 encoding the protein TREACLE.What embryonic tissue is the most affected by this mutation?


A) Endoderm
B) Surface ectoderm
C) Neural crest cells
D) Mesoderm
E) Notochord

F) A) and B)
G) A) and C)

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Researchers have shown that the mandibular prominence can be transformed into the maxillary prominence by the genetic inactivation of two homeobox transcription factors in mice.What are these two factors?


A) Msx1 and -2
B) Barx1 and Msx1
C) Dlx1 and -2
D) Dlx5 and -6
E) Dlx2 and -5

F) D) and E)
G) C) and D)

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The muscles of the larynx are derived from which pharyngeal arches?


A) First
B) Second
C) Third only
D) Fourth and sixth only
E) Third, fourth, and sixth

F) C) and D)
G) All of the above

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Derivatives of the second pharyngeal arches are innervated by which nerves?


A) Cervical spinal nerves
B) Facial nerves
C) Glossopharyngeal nerves
D) Trigeminal nerves
E) Vagus nerves

F) A) and C)
G) C) and D)

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The cheeks are formed from which prominences?


A) Frontal
B) Lateral nasal
C) Mandibular
D) Maxillary
E) Medial nasal

F) All of the above
G) A) and B)

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The stylopharyngeus muscle is innervated by which nerve?


A) Trigeminal
B) Vagus
C) Facial
D) Glossopharyngeal
E) Oculomotor

F) A) and B)
G) A) and C)

Correct Answer

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The muscles of facial expression arise from the mesoderm of which structure(s)


A) First pharyngeal arches
B) Second pharyngeal arches
C) Occipital somites
D) Neural crest cells
E) Notochord

F) A) and B)
G) C) and D)

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The third pharyngeal arch artery gives rise to which adult blood vessel(s) ?


A) Internal and external carotids
B) Common carotids and roots of internal carotids
C) Corticotympanic artery
D) Ductus arteriosus
E) Initial sprouts of pulmonary arteries

F) B) and C)
G) B) and D)

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At birth what is the approximate ratio of the facial skeleton to the cranial vault?


A) 1:3
B) 1:5
C) 1:7
D) 2:1
E) 2:3

F) B) and D)
G) B) and C)

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Van der Woude syndrome is predominantly characterized by which defect?


A) Premature suture closure (i.e., craniosynostosis)
B) Defective outgrowth of the facial processes (i.e., cleft lip and palate)
C) Narrowing of the facial prominences (i.e., holoprosencephaly)
D) Failure of cranial neural tube closure (i.e., exencephaly)

E) None of the above
F) B) and D)

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Both cleft lip and palate have a genetic component,which results in differences in the frequency of cleft lip and palate in females and males.Does cleft lip occur more often in females or males?


A) Males
B) Females

C) A) and B)
D) undefined

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The muscles of mastication,excluding the tongue muscles,arise from the mesoderm of which structure(s) ?


A) First pharyngeal arches
B) Second pharyngeal arches
C) Occipital somites
D) Neural crest cells
E) Notochord

F) D) and E)
G) B) and E)

Correct Answer

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The developing hindbrain is segmented into rhombomeres,which are characterized by the differential expression of members of the Hox family of transcription factors.Researchers have shown that some members of the Hox family are crucial for the specification of the rhombomeres.When Hoxa1 is genetically inactivated in mice,which rhombomeres are affected?


A) r1 and r2
B) r3 and r4
C) r4 and r5
D) r6 and r7

E) None of the above
F) B) and C)

Correct Answer

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