Question 1

Which of the following is true concerning natural killer (NK)  cells?

Accepted Answer

A)   NK cells never express CD16.
B)   NK cells never express CD56.
C)   NK cells express both B and T cell markers.
D)   NK cells do not express B or T cell markers.E) None of the above
F) C) and D) D

Question 2

NKT cells require antigen presentation by:
I- CD1
II- MHC class I molecules
III- MHC class II molecules

Accepted Answer

A)   I only
B)   III only
C)   I and II
D)   II and III
E)   I, II, and IIIF) B) and D)
G) B) and E)

Question 3

A host cell that has been infected with the influenza virus and has subsequently downregulated MHC class I molecules is most likely to be recognized by which cell type?

Accepted Answer

A)   T cell
B)   B cell
C)   NK cell
D)   NeutrophilE) A) and B)
F) None of the above

Question 4

Individuals with Chediak-Higashi syndrome have a genetic defect that causes:

Accepted Answer

A)   The increased production of IL-13
B)   Increased numbers of NKT type I cells
C)   The inability to kill through the perforin and granzymes pathway
D)   The inability to produce activating and inhibiting receptors in the NK cell surfaceE) A) and D)
F) B) and C)

Question 5

Which cell type can kill target cells using the perforin and granzymes method?

Accepted Answer

A)   NKT type I cells
B)   NKT type II cells
C)   NK CD56dim cells
D)   NK CD56bright cellsE) A) and D)
F) All of the above

Question 6

Which is the main surface molecule on NK cells that is involved in antibody-dependent cell-mediated cytotoxicity (ADCC) ?

Accepted Answer

A)   CD3
B)   CD16
C)   CD56
D)   CD94E) B) and D)
F) A) and D)

Question 7

Which of the following cell types may play a role in allergic reactions, particularly in relation to asthma?

Accepted Answer

A)   NK CD56dim cells
B)   NK CD56bright cells
C)   NKT type I cells
D)   NKT type II cellsE) A) and D)
F) All of the above

Question 8

NK cells produce which cytokine that activates macrophages?

Accepted Answer

A)   IL-1
B)   IL-13
C)   TNF-a
D)   Interferon-gE) A) and B)
F) B) and C) D

Question 9

NK cells have cell surface receptors that contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs) , which bind ligand and recruit which type of molecule to transmit the inhibitory signal?

Accepted Answer

A)   cAMP
B)   Kinase
C)   ATPase
D)   PhosphataseE) B) and D)
F) B) and C) D

Question 10

If a host cell expresses both MHC class I molecules and ligands that bind activating receptors on NK cells, what is the outcome for the host cell?

Accepted Answer

A)   The host cell will not be killed because the NK cell needs two different activating signals to kill a host cell.
B)   The host cell will not be killed because the MHC class I molecules cause inhibition that overrides the activating signals.
C)   The host cell will be killed because the NK cell does not bind MHC class I molecules and the activating signal causes cell death.
D)   The host cell will be killed because the activating signal overrides the inhibitory signal caused by the MHC class I molecule binding.E) All of the above
F) A) and B)

Exam 21: Natural Killer Cells

Which of the following is true concerning natural killer (NK) cells?

Correct Answer
verified
D

NKT cells require antigen presentation by: I- CD1 II- MHC class I molecules III- MHC class II molecules

Correct Answer
verified

A host cell that has been infected with the influenza virus and has subsequently downregulated MHC class I molecules is most likely to be recognized by which cell type?

Correct Answer
verified

Individuals with Chediak-Higashi syndrome have a genetic defect that causes:

Correct Answer
verified

Which cell type can kill target cells using the perforin and granzymes method?

Correct Answer
verified

Which is the main surface molecule on NK cells that is involved in antibody-dependent cell-mediated cytotoxicity (ADCC) ?

Correct Answer
verified

Which of the following cell types may play a role in allergic reactions, particularly in relation to asthma?

Correct Answer
verified

NK cells produce which cytokine that activates macrophages?

Correct Answer
verified
D

NK cells have cell surface receptors that contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs) , which bind ligand and recruit which type of molecule to transmit the inhibitory signal?

Correct Answer
verified
D

If a host cell expresses both MHC class I molecules and ligands that bind activating receptors on NK cells, what is the outcome for the host cell?

Correct Answer
verified

Exam 21: Natural Killer Cells

Which of the following is true concerning natural killer (NK) cells?

Correct AnswerverifiedD

NKT cells require antigen presentation by: I- CD1 II- MHC class I molecules III- MHC class II molecules

Correct AnswerverifiedShow Answer

A host cell that has been infected with the influenza virus and has subsequently downregulated MHC class I molecules is most likely to be recognized by which cell type?

Correct AnswerverifiedShow Answer

Individuals with Chediak-Higashi syndrome have a genetic defect that causes:

Correct AnswerverifiedShow Answer

Which cell type can kill target cells using the perforin and granzymes method?

Correct AnswerverifiedShow Answer

Which is the main surface molecule on NK cells that is involved in antibody-dependent cell-mediated cytotoxicity (ADCC) ?

Correct AnswerverifiedShow Answer

Which of the following cell types may play a role in allergic reactions, particularly in relation to asthma?

Correct AnswerverifiedShow Answer

NK cells produce which cytokine that activates macrophages?

Correct AnswerverifiedD

NK cells have cell surface receptors that contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs) , which bind ligand and recruit which type of molecule to transmit the inhibitory signal?

Correct AnswerverifiedD

If a host cell expresses both MHC class I molecules and ligands that bind activating receptors on NK cells, what is the outcome for the host cell?

Correct AnswerverifiedShow Answer

Correct Answer
verified
D

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D

Correct Answer
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D

Correct Answer
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